Dental implants became one of the major preferred treatment options to replace missing teeth for 100 million people, yet over one million implants fail to integrate and lose supporting bone due to peri-implantitis. Multiple etiologic factors have been identified to contribute to this devastating disease, and today’s presentations will allow us to understand the prevalence of peri-implantitis as well as lead to a deep understanding of potential treatment options that have been proven to be successful in the prevention of the disease progression.