The use of regenerative treatment to save failing teeth with advanced periodontal disease has been a part of the periodontist’s armamentarium for decades. What was originally performed using autogenous materials with surgical flap procedures has evolved over time to include procedures that incorporate more minimalistic approaches as well as the use of medical advances including lasers and biologics. This program will address “conventional”, minimally invasive and the use of lasers in periodontal regenerative therapy. Each approach offers unique advantages and disadvantages which will be reviewed allowing comparisons and the opportunity to identify the best possible treatment for our patients.